With a population of around 5,400, Villa de San Antonio sits in Comayagua Department, Honduras. The city operates in the America/Tegucigalpa time zone.
In 2025, Villa de San Antonio recorded an average annual temperature of 77°F. The hottest temperatures reached 101°F in April; the coolest were 60°F in April. Total precipitation for the year was 109 inches, with the wettest month being September.
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