With a population of around 1,400, Rio Sereno sits in Chiriqui Province, Panama. The city operates in the America/Panama time zone.
In 2025, Rio Sereno recorded an average annual temperature of 68°F. The hottest temperatures reached 87°F in March; the coolest were 53°F in April. Total precipitation for the year was 195 inches, with the wettest month being October.
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