Santa Isabel Xiloxoxtla is a city of approximately 4,400 people in Tlaxcala, Mexico. Located in the Central Time Zone at 19.3°N latitude.
In 2025, Santa Isabel Xiloxoxtla averaged an annual temperature of 61°F, with hottest temperatures reaching 87°F in May and lowest around 40°F in November. The city received approximately 42 inches of precipitation during the year.
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