Santa Isabel Xiloxoxtla is a city of approximately 4,400 people in Tlaxcala, Mexico. Located in the Central Time Zone at 19.3°N latitude.
In 2025, Santa Isabel Xiloxoxtla recorded an average annual temperature of 61°F. The hottest temperatures reached 87°F in May; the coolest were 40°F in November. Total precipitation for the year was 42 inches, with the wettest month being June.
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