De Soto is a city of approximately 6,500 people in Missouri, United States. Located in the Central Time Zone at 38.1°N latitude.
In 2025, De Soto averaged an annual temperature of 57°F, with hottest temperatures reaching 96°F in August and lowest around -1°F in February. The city received approximately 41 inches of precipitation during the year.
View historical weather for De Soto · More cities in Missouri