De Soto is a city of approximately 6,500 people in Missouri, United States. Located in the Central Time Zone at 38.1°N latitude.
In 2025, De Soto recorded an average annual temperature of 57°F. The hottest temperatures reached 96°F in August; the coolest were -1°F in February. Total precipitation for the year was 41 inches, with the wettest month being April. Snowfall for the year totaled approximately 6 inches.
View current conditions and forecast for De Soto · More cities in Missouri